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Endocrine Abstracts

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ea0077op3.3 | Reproductive and Neuroendocrinology | SFEBES2021

‘Suppression imaging’ – a novel PET technique for increasing confidence in the localisation of secretory pituitary microadenomas

MacFarlane James , Kourlouri Olympia , Gillett Daniel , Senanayake Russell , Santarius Thomas , Tysome James , Donnelly Neil , Mendichovszky Iosif , Cheow Heok , Mannion Richard , Bashari Waiel , Gurnell Mark

Background: In a sub-group of patients with newly diagnosed pituitary adenomas, conventional MRI will fail to confidently localise the tumour. The role of molecular imaging for these patients is increasingly being recognised, both in terms of confirming diagnosis and in guiding targeted therapy; 11C-Methionine PET co-registered with volumetric MRI (Met-PET/MRCR) can enhance decision making in this group of patients. However, in some cases distinguishing t...
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ea0065op6.1 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Extended TSS (guided by 11C-methionine PET + MRI (Met-PET/MRCR)) can be an effective treatment option for patients with persistent acromegaly due to previously deemed unresectable lateral disease

Bashari Waiel A , Senanayake Russell , Fernandez-Pombo Antia , Gillett Daniel , Koulouri Olympia , Powlson Andrew , Cheow Heok , Mendichovszky Iosif , Kolias Angelos , Tysome James , Santarius Thomas , Mannion Richard , Gurnell Mark

Objective: To determine if an extended lateral approach to trans-sphenoidal surgery (TSS), guided by 11C-Methionine PET/CT co-registered with volumetric MRI (Met-PET/MRCR), can lead to remission in patients with persistent acromegaly due to post-operative lateral/para-sellar tumour remnants.Methods: We identified eight patients with persistent acromegaly following primary intervention [TSS ± medical therapy ± radiotherapy ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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